The full trailer for The Outer Worlds 2's first story DLC, Side Effects Guaranteed, premieres on November 10, 2026, following a short cinematic teaser released on October 29—the game's first anniversary. Obsidian Entertainment has been teasing the expansion throughout October in the series' signature satirical style, joking that the DLC "successfully passed clinical trials" and that this was "in no way connected to certain unfortunate deaths," while also releasing a track titled Anti-Auntie's Choice referencing the in-game Auntie's Choice corporation—suggesting a story about dubious medications and those who profit from them.
Side Effects Guaranteed is the first of two planned story DLCs for The Outer Worlds 2, both included in the Premium Edition and also available for separate purchase. The exact release date for the DLC itself and further story details remain unannounced. The Outer Worlds 2 is available now on PlayStation 5, Xbox Series X|S, and PC (Steam).