Gugliotta was drafted in 1992 out of North Carolina State University with the 6th overall pick by the National Basketball Association's Washington Bullets. In 13 NBA seasons he averaged 13.0 ppg, 7.3 rpg and 2.8 apg over 763 regular season games, but appeared in only 12 playoff games. His best years were with the Minnesota Timberwolves, scoring 20.6 and 20.1 ppg in the 1996-1997 and 1997-1998 seasons. Gugliotta also played for the Golden State Warriors, Phoenix Suns, Boston Celtics, Utah Jazz and the Atlanta Hawks.